Saturday, November 28, 2015
Canadian politics are probably of little interest to the rest of the world, and the recent switch in ruling party most likely went unnoticed by anyone not holding a maple leaf close to their hearts. However, for Canadian science, the recent events are a big deal.
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Friday, November 27, 2015
Krönke et al. (2015) recently used quantitative proteomics and mass spectrometry analysis to examine the mode of action behind lenalidomide’s impressive efficacy in treating del(5q) myelodysplastic syndrome (MDS).1 In conjunction with molecular techniques, they demonstrated that the immunomodulatory (IMiD) agent targets casein kinase 1A1 (CK1α) for proteasomal degradation via ubiquitination. The del(5q) MDS patients show deletion Read the rest of this article
The post Proteomic Evaluation of Lenalidomide Efficacy in del(5q) Myelodysplastic Syndrome appeared first on Accelerating Science.
from Accelerating Science » Amanda Maxwell http://ift.tt/1IebBEL
Thursday, November 26, 2015
|evening snuggles on the couch are simply the best|
As some of you may know, the reason for the amputation was cancer - his radiographs showed something suspicious just below his left elbow. Osteosarcoma in dogs is not pleasant, often causing spontaneous fracture in addition to massive amounts of pain if left untreated. The prognosis with amputation isn't wonderful since metastasis occurs early, but there are things that can be done to extend quality of life and even minimise occurrence.
However, Rosco's histopath results, which eventually came back on Tuesday, show not osteosarcoma but a very odd hyperproliferative boney reaction going on. All three vets involved in his case (me included) are stumped by what was going on below his er, stump.
Since chemotherapy is proven value in minimising osteosarc mets and since Rosco has such an odd histopath result, weve asked the pathologists to look at more sections just in case the tumour is eluding detection. We may even ask for a second histopath opinion, and we're getting an second radiological consult too ... all in a hurry as we don't want to miss the window of opportunity to tackle a tumour if this is the case.
So we're cautiously optimistic that we just have a weird dog on our hands.
Rosco meanwhile is bounding (and I do mean bounding) along in rude health. He now lopes at a pretty rapid pace and needs very few stops on his daily walks. We're still not taking him the distance, staying only to local short walks but I think we'll start extending his range soon.
We should know soon if Christmas will be a cancer-free or a chemo-abundant one.
Right now we're just enjoying having a dog who is so obviously pain-free and happy, allbeit on three legs.
Wednesday, November 25, 2015
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Monday, November 23, 2015
Sunday, November 22, 2015
Friday, November 20, 2015
read more : from The V3H.com - Port Moody, Coquitlam, Port Coquitlam » Amanda Maxwell http://ift.tt/1Ms6QGsvia IFTTT
|a cheat in progress?|
Yesterday's post was on growing your own gut.
Now - why would you want to grow your own gut?
As it turns out, growing your own gut - or to be more correct, growing gut organoids - is a good thing for drug and disease research. The little gut-lets grown in vitro are great substitutes for real guts, letting researchers avoid the great lab rodent sacrifice and simultaneously giving them access to a patient's individual enteric peculiarities. By banking loads of individual gut explants for organoid culture, more research can be done to unravel the links between genomics and disease, which is a first step in providing individualized, tailored therapies for conditions such as cancer.
Imagine being able to grow your own test piece of gut in a dish and using it to test for drugs that will be effective just for you!
Magic, and not that far off.